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Most rushing yards in the 2000s decade, National Football League
LaDainian Tomlinson has rushed for the most yards from 2000 to 2009, with 12492.

Archive coverage
StatPro NFL regular-season records: 2000–2009. Requested: 2000 through 2009.
- 12492
- LaDainian Tomlinson
| # | Player | Team | Rushing yards |
|---|---|---|---|
| 1 | 12492 | ||
| 2 | Edgerrin James | 10701 | |
| 3 | Jamal Lewis | 10603 | |
| 4 | Clinton Portis | 9696 | |
| 5 | 9585 | ||
| 6 | Tiki Barber | 9513 | |
| 7 | Shaun Alexander | 9445 | |
| 8 | Thomas Jones | NYJ | 9212 |
| 9 | Ahman Green | 8876 | |
| 10 | Warrick Dunn | 8345 |