Jeremy Peña (wrist) is not in the lineup for Wednesday’s game against the Mariners.

It’s a significant loss for the Astros after Peña was drilled by a pitch on the right wrist during Tuesday’s series-opening win over Seattle that put them back in the driver’s seat in the AL West division race. The positive news is that X-rays came back negative for any fractures. Peña appears to have avoided a serious injury, but he’ll likely need some time off for the pain and swelling to subside before he’s ready to return. It’ll be defensive specialist Nick Allen taking over at shortstop and hitting ninth in his absence.