ESPN’s Jeremy Fowler reports that Talanoa Hufanga is expected to miss “about 2-3 weeks” with an ankle injury.

The former second-team All-Pro safety left last week’s game against the Chargers with the injury. Hufanga has been one of the biggest havoc creators in the league this year with one forced fumble and two interceptions, one of which was returned for a touchdown. His absence will be a big blow to the Broncos’ defense, which is already without Patrick Surtain II, Jonathon Cooper, and potentially Riley Moss for their Week 6 matchup against the Seahawks.