Regular season · Passing
| 2021 | WAS | 1 | 3 | 6 | 13 | 0 | 0 | 1 |
| 2020 | MIA | 9 | 183 | 267 | 2091 | 13 | 8 | 14 |
| 2019 | MIA | 15 | 311 | 502 | 3529 | 20 | 13 | 40 |
| 2018 | TB | 8 | 164 | 246 | 2366 | 17 | 12 | 14 |
| 2017 | TB | 6 | 96 | 163 | 1103 | 7 | 3 | 7 |
| 2016 | NYJ | 14 | 228 | 403 | 2710 | 12 | 17 | 19 |
| 2015 | NYJ | 16 | 335 | 562 | 3905 | 31 | 15 | 19 |
| 2014 | HOU | 12 | 197 | 312 | 2483 | 17 | 8 | 21 |
| 2013 | TEN | 11 | 217 | 350 | 2454 | 14 | 12 | 21 |
| 2012 | BUF | 16 | 306 | 505 | 3400 | 24 | 16 | 30 |
| 2011 | BUF | 16 | 353 | 569 | 3832 | 24 | 23 | 22 |
| 2010 | BUF | 13 | 255 | 441 | 2992 | 23 | 15 | 24 |
| 2009 | BUF | 10 | 127 | 227 | 1422 | 9 | 10 | 22 |
| 2008 | CIN | 12 | 221 | 372 | 1905 | 8 | 9 | 38 |
| 2005 | STL | 4 | 76 | 135 | 777 | 4 | 8 | 9 |
| Career | TOTAL | 163 | 3072 | 5060 | 34982 | 223 | 169 | 301 |
Regular season · Rushing & receiving
| 2021 | WAS | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2020 | MIA | 9 | 30 | 151 | 2 | 1 | 1 | 0 | 0 | 0 |
| 2019 | MIA | 15 | 54 | 243 | 4 | 0 | 0 | 0 | 0 | 2 |
| 2018 | TB | 8 | 36 | 152 | 2 | 0 | 0 | 0 | 0 | 1 |
| 2017 | TB | 6 | 15 | 78 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2016 | NYJ | 14 | 33 | 130 | 0 | 0 | 0 | 0 | 0 | 1 |
| 2015 | NYJ | 16 | 60 | 270 | 2 | 0 | 0 | 0 | 0 | 2 |
| 2014 | HOU | 12 | 50 | 184 | 2 | 0 | 0 | 0 | 0 | 1 |
| 2013 | TEN | 11 | 43 | 225 | 3 | 1 | 1 | 0 | 0 | 2 |
| 2012 | BUF | 16 | 48 | 197 | 1 | 0 | 0 | 0 | 0 | 6 |
| 2011 | BUF | 16 | 56 | 215 | 0 | 0 | 0 | 0 | 0 | 2 |
| 2010 | BUF | 13 | 40 | 269 | 0 | 0 | 0 | 0 | 0 | 5 |
| 2009 | BUF | 10 | 31 | 141 | 1 | 0 | 0 | 0 | 0 | 2 |
| 2008 | CIN | 12 | 60 | 304 | 2 | 1 | 1 | -3 | 0 | 5 |
| 2006 | STL | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2005 | STL | 4 | 14 | 64 | 2 | 0 | 0 | 0 | 0 | 1 |
| Career | TOTAL | 164 | 574 | 2625 | 21 | 3 | 3 | -3 | 0 | 30 |
